TDM plug-ins are processed on DSP chips so it's highly doubtful. You should ask the plug-in manufacturer to consider porting specific plug-ins to the native form if there's something specific you require. At the moment it's not worth it anyway as PT isn't 64-bit.
We have multiple customer reports after upgrading to Lion about MusicLab RealGuitar/RealStrat/RealLPC instruments showing "Guitars no found" message after loading instruments in ProTools 9/10. That means our Real instruments do not "see" sound bank file in /Applications/RealGuitar2, RealStrat, RealLPC folders. VST to RTAS version is 2.1. The same config works fine in 10.6.8. I guess it is some kind of security permissions issue. Could you please advise?